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Core Clinical, 1 month. 3 sabores
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NOVOS Core Clinical
The first formulation designed to address all 12 biological Hallmarks of Aging, now supported by 7+ years of R&D and randomized, placebo-controlled human clinical research, showing positive results for functional markers of cardiovascular and overall aging.
NOVOS Core Clinical is the first formulation designed around all 12 biological Hallmarks of Aging, developed with leading longevity scientists and physicians specializing in aging biology.
Backed by more than seven years of R&D, it has been evaluated in randomized, double-blind, placebo-controlled human clinical research demonstrating statistically significant effects across validated measures of endothelial function, arterial flexibility, and systolic blood pressure in the normal range, with effect sizes among the largest reported in published human research for a supplement, nutritional, or lifestyle intervention.
Built as a coordinated, multi-pathway system rather than a single-ingredient solution, NOVOS Core Clinical is designed to support multiple aging-related systems at once. In addition to cardiovascular outcomes, research has observed favorable shifts in biological age markers measured epigenetically and improvements in skin firmness in preliminary human studies, alongside customer-reported benefits such as steadier energy, mental clarity, mood balance, and sleep consistency†. The formulation is further supported by mechanistic studies and preclinical lifespan research, providing multi-level scientific evidence that NOVOS Core Clinical supports foundational aspects of healthy aging biology.*
A system designed to support the biology of aging itself
Aging doesn’t happen in one place. It emerges from interconnected biological processes that influence cardiovascular function, cellular energy production, tissue renewal, and resilience across the body.
NOVOS Core Clinical was intentionally designed around the biology of aging itself — not individual symptoms — by supporting all 12 biological Hallmarks of Aging simultaneously. Developed with scientists and physicians affiliated with institutions including Harvard Medical School, MIT, and the Salk Institute, the formulation is built as a coordinated system designed for ingredient synergy rather than a collection of isolated or trendy ingredients.
Because these foundational systems shape how the body functions day to day, supporting them can influence performance, resilience, and overall well-being long before later-life outcomes become relevant.
Built on evidence, not theory
NOVOS Core Clinical is supported by multiple layers of research:
- Mechanistic studies to understand how it influences aging-related biological pathways
- Preclinical lifespan studies in mice, where animals receiving NOVOS Core Clinical Clinical lived over 18% longer on average (animal models do not predict human outcomes and are not indicative of impact on humans)
- Randomized, placebo-controlled human clinical research using validated functional biomarkers commonly applied in cardiovascular and aging science
This multi-level approach reflects an uncommon standard of scientific validation for a nutritional formulation — testing the complete system rather than relying on individual ingredient claims.
What the formulation is designed to support
Cellular energy & metabolic efficiency
Supports mitochondrial and metabolic pathways involved in cellular energy production to help maintain stamina, clarity, and daily recovery.
Healthy cellular renewal
Supports the body’s natural renewal and turnover processes that help maintain tissue function over time.
Cellular resilience & stability
Supports DNA stability, cellular stress-response pathways, and healthy inflammatory balance to promote long-term cellular function.
Protein quality & cellular communication
Supports proteostasis, extracellular matrix structure, and intercellular signaling — helping tissues remain coordinated and responsive with age.
Why this approach is different
Most supplements focus on isolated ingredients or single outcomes, while few are rigorously evaluated as complete formulations in randomized, placebo-controlled human clinical trials using validated functional biomarkers.
NOVOS Core Clinical was designed to support the biology of aging as a connected system and evaluated as a complete formulation through mechanistic research, preclinical lifespan studies, and human clinical trials — not trends, theories, or ingredient-by-ingredient claims.*
Few dietary supplements are evaluated this way, testing the complete finished formula in humans rather than relying on ingredient-level assumptions.
Each ingredient in NOVOS Core Clinical was selected based on scientific evidence and is either naturally present in human biology or derived from compounds found in nature. Together, they were chosen for their roles in aging-related biological pathways and for their established safety profiles in human research.
1. Calcium Alpha-Ketoglutarate (Ca-AKG) - A compound naturally present in human metabolism that supports mitochondrial energy production and cellular resilience.
2. Fisetin - A polyphenol found in strawberries and other fruits that supports cellular renewal and healthy inflammatory balance.
3. Pterostilbene - An antioxidant compound found in blueberries that supports cardiovascular and metabolic health.
4. Glucosamine Sulfate – Naturally occurring in connective tissues, supports joint and extracellular matrix integrity.
5. Glycine – An amino acid abundant in collagen that supports recovery, detoxification, and restorative sleep.
6. Magnesium Malate – A form of magnesium involved in ATP production that supports energy metabolism and muscle function.
7. L-Theanine – An amino acid found in green tea that supports calm focus and stress resilience.
8. Rhodiola Rosea – An adaptogenic root traditionally used to support stamina, mental performance, and stress response.
9. Gingerols & Shogaols – Bioactive compounds from ginger that support healthy inflammatory signaling and digestive comfort.
10. Hyaluronic Acid – A molecule naturally present in skin and joints that supports hydration, elasticity, and tissue resilience.
11. Vitamin C – An essential nutrient found in fruits and vegetables that supports collagen production, antioxidant protection, and synergizes with CaAKG.
12. Micro-dosed Lithium – A trace mineral found naturally in water and foods that supports neuronal signaling and mood balance.
These statements have not been evaluated by the Food and Drug Administration. This product/information is not intended to diagnose, treat, cure, or prevent any disease.
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Core Clinical, 1 month. 3 sabores